目前分類:Learning objects (53)

瀏覽方式: 標題列表 簡短摘要

Neuropathy v.s. Myopathy:

http://www.cidpusa.org/weakness.htm

 

Aphasia Classification:

http://www.healthatoz.com/healthatoz/Atoz/common/standard/transform.jsp?requestURI=/healthatoz/Atoz/ency/aphasia.jsp

http://www.aphasia.com/wordpdf/CCMCAphasiaClassif25A255.pdf

 

CNS

http://biology.about.com/gi/dynamic/offsite.htm?site=http://www.geocities.com/HotSprings/3468/11%2D01.html%23Medulla

 

Sensory Tract (Chinese)

http://homepage.mac.com/mehu2000/CSMU/Neuroanatomy/Sensory%20System.htm

 

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胎兒監視與胎兒窘迫(Fetal Monitoring and Fetal Distress)
胎兒監視(Fetal Monitoring)
前言
胎兒監視的主要目的是檢查出潛在性的胎兒危險。現今最常用的是用生物物理 (Biophysical) 方法來評估胎盤功能。另外還有用生物化學 (Biochemical) 方法者,但已漸漸被前者取代而少用了。
適應症
主要是針對高危險妊娠,可歸類如下:
(1) Hypertensive disorders
(2) D.M.
(3) Post-term pregnancy
(4) IUGR
(5) History of previous stillbirth
(6) Anemia
(7) Hemoglobinopathies
(8) Decreased fetal movements
(9) Cyanotic heart disease
(10) Collagen vascular disease
(11) Preterm labor and PROM
(12) Other
生物物理方法 (Biophysical testing)
(1) NST(不加壓試驗)
A. 操作法:
a. 孕婦平臥於檢查檯上。
b. 裝上宮縮及胎心記錄器。
c. 有自覺胎動時做記號於記錄紙上。
d. 記錄20分鐘宮縮及胎心率。
B. 禁忌症:無
C. 判讀:
b. Non-reactive:沒有達到以上 "reactive" 標準者,稱之。一般而言,false positive rate 很高,要先排除 fetal sleep 及 sedative drugs。若無足夠胎動,可令孕婦吃含糖食物或飲料,推動孕婦腹部,或使用 artificial larynx刺激,這就是所謂的 Acoustic stimulation test (AST)。
(2) CST (Contraction stimulation test):
A. 操作法:
a. 孕婦平臥於檢查檯上。
b. 裝上宮縮及胎心記錄器,先作 10-15 分鐘的基礎心搏率。
c. 刺激乳頭或以 IV pitocin 刺激,直到每 10 分鐘有 3 次宮縮且持續 40 秒以上。
d. 做完後須監視到無宮縮為止。
B. 禁忌症:
a. 前置胎盤。
b. 前次子宮直式剖腹產或子宮破裂。
c. 早發性陣痛。
d. 子宮頸閉鎖不全。
e. 早期破水。
f. 多胎妊娠或羊水過多。
C. 判 讀:
a. Negative:子宮收縮每10分鐘有3次且持續40秒以上的狀況下,無遲發性減速的現象。
b. Equivocal:inconsistent late deceleration.
c. Positive:遲發性減速伴隨半數以上的宮縮。(但須排除子宮過度收縮的情形)
d. Hyperstimulation:宮縮間隔小於2分鐘或持續時間大於90秒。
e. Unsatisfactory:宮縮未能達到標準,或胎心紀錄不良。
(3) Biophysical profile (BPP) 胎兒生理活動評估
1980 年由 Manning 提出,其偽陰性 (0.634/1000) 比 CST 略高,但無副作用,且無禁忌症,比單純的 NST 更為準確。
A. 方法:含五項評分標準,有則2分,無則0分
B. 結果與意義:
Antepartum testing protocol
生物化學方法 (Biochemical test)
包括測量 E3 與 HPL (human placental lactogen)
(1) E3 可定量血液或 24 小時之小便。
(2) HPL 則是由 Cytotrophoblast 釋放到母體循環中。
(3) 由於實驗室設備昂貴,檢驗費時而誤差大。已被胎兒理學檢查所取代,現已少做。
胎兒窘迫 (Fetal distress)
(1) 定義:定義不明確,通常將之和胎兒窒息視同一致。而胎兒窒息則通常定義為有胎兒低血氧,高血中二氧化碳及代謝性酸中毒的情況。
(2) 症狀:
慢性胎兒窘迫,是胎盤機能因過期妊娠或有妊娠毒血症或糖尿病而引起機能不全,導致生長遲滯。
急性胎兒窘迫,是因子宮壁肌肉收縮而引起血液循環暫時停止。缺氧程度輕重不同,造成胎兒心跳的影響就有不同,胎心加速,可能是刺激交感神經而來,胎心變慢,可分為三種。
早發性減速因胎頭壓迫引起,其特徵為形狀一致且減速開始在宮縮期之早期。
晚發性減速因胎盤機能不全,其特徵為形狀一致且減速開始在宮縮期之末期。
不定性減速因臍帶壓迫引起,其特徵為形狀有變異且減速之開始與宮縮之開始間的時間關係不定。
(3) 診斷
應用胎兒監視器來診斷胎兒窘迫可分為兩種。一為產前的診斷約28週以後應用 OCT,如果發現 late deceleration 或胎心搏變異性消失,即表示有胎兒窘迫現象。
另一為分娩中胎兒窘迫的診斷。其判讀的基本原則參考以下
A. Reassuring FHR Patterns
a. Baseline FHR between 120 and 160 bpm (100--120 and 160--180 also accepted)
b. Good short-term baseline variability (5--15 bpm)
c. No change in FHR baseline with contractions
d. Accelerations with contractions or fetal movements
e. Mild to moderate Type I decelerations
B. Nonreassuring FHR Patterns
a. Tachycardia > 180
b. Bradycardia < 100
c. Decreased beat-to-beat variablilty < 5 bpm
d. Severe (Type Ⅰ) deceleration < 60 bpm
e. Late (Type Ⅱ) deceleration of any magnitude
f. variable (Type Ⅲ) deceleration of moderate to severe magnitude
(4) 臨床處置
A. 母體位置改變,由仰臥位改為側臥位,以改善仰臥性低血壓或改善不定性胎心搏減速。
B. 矯正母體低血壓:改變母體位置或提高腳部或靜脈注射點滴。
C. 減低宮縮壓力或使宮縮一致化 (synchronized):使宮縮間隔拖長,讓胎兒窘迫得有改善的機會。
D. 母體氧氣吸入:可以提高母體胎兒間氧氣分壓差。O2 mask 8-10 liter/min。
                                        E. 若母體血壓過低,要矯正其 hypotension。
臍帶脫垂 (Cord prolapse)
(1) 定義:
可分為三種:
A. Occult prolapse:臍帶掉入骨盆,但不超過先露部,無法以手指檢查得到。
B. Forelying cord:臍帶在先露部之前,但羊膜還沒有破。
C. True prolapsed cord:羊膜破了,臍帶在先露部之前,通常被壓迫。
(2) 病因:
有各種不同原因都會引起臍帶脫垂,歸納如下:
A. Prematurity
B. Transverse lie
C. Incomplete breech
D. Compound presentation
E. Multiparity
F. Cephalopelvic disproportion
G. Leiomyoma uteri
H. Multiple pregnancy
I. Partial placenta previa
J. High fetal station
(3) 診斷:
A. Occult prolapse 通常要靠胎兒監視上的不定性胎心搏遲緩看出來。有時候臍繞頸也可用超音波掃描可以查到。
B. Forelying 及 True cord prolapse 則作內診時都可以查到。或胎心搏記錄也可知道。
(4) 處置:
A. Forelying cord:剖腹生產。
B. Occult prolapse:裝上胎兒監視器,如果胎心搏不好,則作剖腹產。如果有改善、等待、等先露部下降後,再看胎心變化,如果胎心變不正常,則作剖腹產,如果胎心搏正常,則繼續觀察之。
C. True cord prolapse:提高胎兒先露部,給氧氣,手進去抵著胎兒先露部。連絡開刀房,送開刀,並一直注意胎心搏的變化。
 

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http://www.ds-health.com/prenatal.htm

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1. Normal Uric acid levels are 2.4-6.0 mg/dL (female) and 3.4-7.0 mg/dL (male).
2. Normal levels of creatinine in the blood are approximately 0.6 to 1.2 mg/dl (male) and 0.5 to 1.1  mg/dl (female)
3. Normal BUN levels are 5-18 mg/dL for children; 7-18 mg/dL for adults; and 8-20 mg/dL in the elderly.
4.  Prolactin level: adult male: 0-20 ng/ml , adult female: 0-20 ng/ml , pregnant female: 20-400 ng/ml

cf. 2. http://www.medicinenet.com/creatinine_blood_test/article.htm
3. http://www.healthatoz.com/healthatoz/Atoz/common/standard/transform.jsp?requestURI=/healthatoz/Atoz/ency/blood_urea_nitrogen_test.jsp
4. http://www.healthatoz.com/healthatoz/Atoz/common/standard/transform.jsp?requestURI=/healthatoz/Atoz/ency/prolactin_test.jsp

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  • May 20 Tue 2008 00:14
  • OCPs


http://en.wikipedia.org/wiki/Combined_oral_contraceptive_pill#Formulations

Formulations

Oral contraceptives come in a variety of formulations. The main division is between combined oral contraceptive pills, containing both estrogen and progestins and progestin only pills(mini-pills). Combined oral contraceptive pills also come in varying types, including varying doses of estrogen, and whether the dose of estrogen or progestin changes from week to week.

Progestin only pills:
http://en.wikipedia.org/wiki/Oral_contraceptive_formulations

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有音調連續音:
  Wheezing--高頻
  Rhonchi--低頻

無音調不連續音:
Crackle:
  Coarse--粗
  Fine crackle (=rales?)--細(類似小泡泡破掉的聲音)

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ANC: absolute neutrophil count
ANC=(band+segment)%*WBC count

ANC: absolute neutrophil count
絕對嗜中性白血球
1500以下不能打化療藥
1500-2000以下  保護性隔離
500以下  無菌性嚴格隔離

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"止痛藥"是一種泛稱,究竟是代表哪些藥物呢?

原來NSAID也算是止痛藥~~消炎鎮痛阿:P



An analgesic (colloquially known as a painkiller) is any member of the diverse group of drugs used to relieve pain (achieve analgesia). The word analgesic derives from Greek an- ("without") and -algia ("pain"). Analgesic drugs act in various ways on the peripheral and central nervous systems; they include paracetamol (acetaminophen), the non-steroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, narcotic drugs such as morphine, synthetic drugs with narcotic properties such as tramadol, and various others.

In choosing analgesia, the severity and response to other medication determines the choice of agent; the WHO "pain ladder", originally developed in cancer-related pain, is widely applied to find suitable drugs in a stepwise manner.[1] The choice of analgesia is also determined by the type of pain: for neuropathic pain, traditional analgesia is less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants.[2]

From wikipenia

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神經科:
EEG判讀 (alpha, beta waves..)
Hx 的重點事項(語言發展遲緩:特別注意和家人、他人的互動情形)
Development milestone(時間點很重要)

健兒門診:
小兒PE(五官鏡:檢查是否斜視、ears、throat)(眼底鏡:對稱的橘紅色亮點,若變白點,要注意)
  (DDH-development dysplasia of hip的檢查)
Hemangioma、脂漏性皮膚炎
cephalohematoma
G6PD

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http://www.med-ed.virginia.edu/courses/path/innes/wcd/leukocytosis.cfm

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Introduction

Cellulitis is an inflammation of the connective tissue underlying the skin that can be caused by bacterial infection. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion. The mainstay of therapy remains treatment with appropriate antibiotics. Skin on the face or lower legs is most commonly affected by this infection, though cellulitis can occur on any part of the body. Cellulitis may be superficial — affecting only the surface of the skin — but cellulitis may also affect the tissues underlying the skin and can spread to the lymph nodes and bloodstream.

Cellulitis is unrelated to cellulite, a cosmetic condition featuring dimpling of the skin.

Symptoms

Early symptoms may include fever, headache, nausea, and early signs of redness on the affected area.

Cellulitis is characterized by redness, swelling, warmth, and pain or tenderness. Cellulitis frequently occurs on exposed areas of the body such as the arms, legs, and face. Other symptoms can include fever or chills and headaches. In advanced cases of cellulitis, red streaks (sometimes described as 'fingers') may be seen traveling up the affected area. The swelling can spread rapidly.

Causes

Cellulitis is caused by a type of bacteria entering by way of a break in the skin. This break need not be visible. Group A Streptococcus and Staphylococcus are the most common of these bacteria, which are part of the normal flora of the skin but cause no actual infection until the skin is broken. Predisposing conditions for cellulitis include insect bite, animal bite, tattoos, pruritic(搔癢症的) skin rash, recent surgery, athlete's foot, dry skin, eczema, injecting drugs (especially subcutaneous or intramuscular injection or where an attempted IV injection "misses" or blows the vein); plus burns and boils, though there is debate as to whether minor foot lesions contribute and also morbidly(不健全地,病態地) obese people can experience it.

The appearance of the skin will help a doctor make a diagnosis. The doctor may also suggest blood tests, a wound culture or other tests to help rule out a blood clot deep in the veins of the legs. Cellulitis in the lower leg is characterized by signs and symptoms that may be similar to those of a clot occurring deep in the veins, such as warmth, pain and swelling.

This reddened skin or rash may signal a deeper, more serious infection of the inner layers of skin. Once below the skin, the bacteria can spread rapidly, entering the lymph nodes and the bloodstream and spreading throughout the body.

In rare cases, the infection can spread to the deep layer of tissue called the fascial lining. Necrotizing fasciitis, also called by the media "flesh-eating bacteria", is an example of a deep-layer infection. It represents an extreme medical emergency.

Risk factors

The elderly and those with weakened immune systems are especially vulnerable to contracting cellulitis. Diabetics are more susceptible to cellulitis than the general population because of impairment of the immune system; they are especially prone to cellulitis in the feet because the disease causes impairment of blood circulation in the legs leading to foot ulcers. Poor control of blood glucose levels allows bacteria to grow more rapidly in the affected tissue and facilitates rapid progression if the infection enters the bloodstream. Neural degeneration in diabetes means these ulcers may not be painful and thus often become infected.

Immunosuppressive drugs, HIV, and other illnesses or infections that weaken the immune system are also factors that make infection more likely. In addition, chickenpox and shingles(帶狀皰疹) often result in blisters(水泡) which break, providing a gap in the skin through which bacteria can enter. Lymphedema, which causes swelling on the arms and/or legs, can also put an individual at risk.

       Diseases that affect blood circulation in the legs and feet, such as chronic venous insufficiency and varicose veins, are also risk factors for cellulitis.

Cellulitis is also extremely prevalent(行的) amongst dense populations sharing hygiene facilities and common living quarters. Military installations which require communal showers provide such an environment, as it is prevalent among many recruits going through boot camp.

Diagnosis

Cellulitis is most often a clinical diagnosis, and local cultures do not always identify the causative(成為原因的) organism. Blood cultures usually are positive only if the patient develops generalized sepsis. Conditions that may resemble cellulitis include deep vein thrombosis, which can be diagnosed with a compression leg ultrasound, and stasis dermatitis, which is inflammation of the skin from poor blood flow.

Duration

In many cases, cellulitis takes less than a week to disappear with antibiotic therapy. However, it can take months to resolve completely in more serious cases, and can result in severe debility(衰弱) or even death if untreated especially if the symptoms are caused in women. If it is not properly cured it may appear to improve but can resurface again even after months and years.

Treatment

Antibiotics — typically a combination of intravenous and oral antibiotics — are administered. Bed rest and elevation of affected limbs is also recommended. Often physicians suggest patients drink plenty of fluids as well.

 

 http://en.wikipedia.org/wiki/Cellulitis

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Homans sign is said to be present when passive dorsiflexion of the ankle by the examiner elicits(引發) sharp pain in the calf(小腿). It is caused by a thrombosis of the deep veins of the leg. This sign is frequently elicited in clinical practice because of the ease of use, although it is falling into disfavor(不利) because of risk of producing an embolism and because it is frequently positive in individuals without DVT. It is named for the American physician John Homans.

To test for Homans' sign, flex the patient's knee slightly with one hand and, with the other, dorsiflex the foot. The complaint of calf pain with this procedure is a positive sign and often indicates venous thrombosis. Absence of Homans' sign does not preclude(排除) venous thrombosis.

 

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  http://intermargins.net/intermargins/IsleMargin/DrugLib/articles/article03.htm

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http://www.pohai.org.tw/web-internet/pgy/PGY-網路用/教材區/一般醫學內科/Beta%20blockers..ppt

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http://www.youtube.com/watch?v=KXROnzpsrlg
天哪~~~真是超爆笑的~~~
也太快了吧....

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  • Grade 1 - Trivial lack of awareness; Euphoria or anxiety; Shortened attention span; Impaired performance of addition. 67% of cirrhotic patients may have 'minimal hepatic encephalopathy'.[5]
  • Grade 2 - Lethargy or apathy; Minimal disorientation for time or place; Subtle personality change; Inappropriate behavior; Impaired performance of subtraction
  • Grade 3 - Somnolence to semistupor, but responsive to verbal stimuli; Confusion; Gross disorientation
  • Grade 4 - Coma (unresponsive to verbal or noxious stimuli) http://www.gastroresource.com/gitextbook/en/chapter14/14-13.htm

    Table 289–4. Clinical Stages of Hepatic Encephalopathy

    StageMental StatusAsterixisEEG
    IEuphoria or depression, mild confusion, slurred speech, disordered sleep+/–Triphasic waves
    IILethargy, moderate confusion+Triphasic waves
    IIIMarked confusion, incoherent speech, sleeping but arousable+Triphasic waves
    IVComa; initially responsive to noxious stimuli, later unresponsiveDelta activity

    Table 289–3. Common Precipitants of Hepatic Encephalopathy

    Increased nitrogen load

     Gastrointestinal bleeding

     Excess dietary protein

     Azotemia

     Constipation

    Electrolyte and metabolic imbalance

     Hypokalemia

     Alkalosis

     Hypoxia

     Hyponatremia

     Hypovolemia

    Drugs

     Narcotics, tranquilizers, sedatives

     Diuretics (see "Electrolyte imbalance")

    Miscellaneous

     Infection

     Surgery

     Superimposed acute liver disease

     Progressive liver disease

     Portal-systemic shunts

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CKD病人用藥的調整
http://www.aafp.org/afp/20070515/1487.html
GFR Scr Ccr 的relationship
http://www.medscape.com/viewarticle/533695_2

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http://www.cgmh.com.tw/intr/intr2/c3100/update/3-4/rt.htm

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Bronchiectasis
Cause, Clinical presentation, treatment 
http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2006;volume=1;issue=1;spage=41;epage=51;aulast=AL-Shirawi
(eMedicine)causes
http://www.emedicine.com/med/topic246.htm

Cor pulmonale 肺心症
實質或血管的變化,造成右心室肥大或心臟衰竭,叫做肺心症,大多生於大人,小孩子較少見。 
Definition, Pathophysiology
http://www.merck.com/mmpe/sec07/ch074/ch074c.html
(eMedicine)Pathophysiology

http://www.emedicine.com/med/topic449.htm

Pneumonia
Topic overview(diagnose, treatment)
http://www.webmd.com/a-to-z-guides/pneumonia-topic-overview
guideline (Taiwan)
www.mmh.org.tw/taitam/int_med/educ/guideline/Guidelines_PNEUMONIA.ppt

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http://www.webmd.com/heart-disease/tc/heart-attack-and-unstable-angina-symptoms

People who have unstable angina often describe their pain as:

  • Starting within the past 2 months and becoming more severe.
  • Limiting their physical activity.
  • Suddenly becoming more frequent, severe, or longer-lasting or being brought on by less exertion than before.
  • Occurring at rest with no obvious exertion or stress-it may wake the person up.
  • Not responding to rest or nitroglycerin.

http://www.nlm.nih.gov/medlineplus/ency/article/000201.htm#Symptoms

Symptoms include:

  • Sudden chest pain that may also be felt in the shoulder, arm, jaw, neck, back, or other area
  • Pain that feels like tightness, squeezing, crushing, burning, choking, or aching
  • Pain that occurs at rest and does not easily go away when using medicine

If you have stable angina, and the chest pain starts to feel different, lasts longer than 15 - 20 minutes, or occurs at different times, you may be developing unstable angina.

 

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