低於正常值表示有hemolysis
http://en.wikipedia.org/wiki/Haptoglobin
UpToDate: Approach to the diagnosis of hemolytic anemia in the adult
Serum LDH and haptoglobin — Two major tests used to diagnose the presence of hemolysis are lactate dehydrogenase (LDH, specifically the LD1 and LD2 isoforms), released from hemolyzed RBCs, and haptoglobin, which binds to hemoglobin released during intravascular or extravascular hemolysis or ineffective erythropoiesis with release of hemoglobin from late erythroid precursors in the bone marrow. Higher haptoglobin values in the presence of hemolysis can reflect either a lesser degree of hemolysis or concurrent inflammation, since haptoglobin is an acute phase reactant. (See "Acute phase reactants").
In one series of reports, the combination of an increased serum LDH and a reduced haptoglobin was 90 percent specific for diagnosing hemolysis, while the combination of a normal serum LDH and a serum haptoglobin >25 mg/dL was 92 percent sensitive for ruling out hemolysis [17,18]. However, in practice, the normal range for serum haptoglobin is wide, with the lower limits of normal in the range of 17 to 35 mg/dL in some laboratories. Thus, while low levels of haptoglobin are often seen, undetectable levels (eg, <7 mg/dL) are almost always associated with clinical hemolysis.
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